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Where Wang 2023

Top-loaded gradients tend to give a lower yield of oocyst walls than do bottom-loaded gradients

Among the most important are (i) the TGF- signaling pathway that triggers downstream events such as the expression of connective tissue growth factor (CTGF), (ii) pathological mechanical forces (mechanotransduction) that occur through overload, repetitive stress or injury, (iii) pro-inflammatory cytokines and innate immunity in a persistent inflammatory environment, and (iv) excessive oxidative stress leading to cellular aging and senescence ( Figure 5 ) (90)

Respuesta al tratamiento: La magnitud de la respuesta individual es crucial