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For mild symptoms (nausea, diarrhoea, mild weakness): Immediately stop taking magnesium supplements and any magnesium-containing medications (laxatives, antacids) Increase fluid intake to support renal excretion, provided kidney function is normal Contact your GP or NHS 111 for advice, particularly if symptoms persist beyond 24 hours or worsen Review all medications and supplements to identify potential magnesium sources Avoid resuming supplementation without medical guidance For moderate to severe symptoms (significant muscle weakness, breathing difficulties, chest pain, irregular heartbeat, confusion, or profound lethargy): Call 999 immediately or proceed to the nearest Accident & Emergency department Do not attempt to induce vomiting or take additional substances If possible, bring all supplement bottles and medications to hospital for identification Inform healthcare providers about the type, dose, and duration of magnesium supplementation Hospital management of magnesium toxicity may include: Intravenous calcium gluconate : acts as a direct antagonist to magnesium's cardiac and neuromuscular effects Intravenous fluids : often with loop diuretics to promote renal excretion in patients with adequate kidney function Haemodialysis : for severe cases or those with renal impairment, effectively removing excess magnesium Cardiac monitoring : continuous ECG surveillance to detect arrhythmias Respiratory support : including mechanical ventilation if respiratory depression occurs Following recovery , patients should undergo assessment to determine why toxicity occurred

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This overlapping approach allows the new medication time to reach therapeutic levels before GLP-1 support is fully withdrawn

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