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Mast cell (MC)-derived histamine and H4R drove experimental colitis, as H4R / mice had lower symptom scores, neutrophil-recruitment mediators (colonic interleukin-6 (IL-6), CXCL1, CXCL2), and mucosal neutrophil infiltration than wild-type (WT) mice, as did MC-deficient Kit W-sh/W-sh mice reconstituted with histidine decarboxylasedeficient ( HDC / ) bone marrowderived MCs compared with WT-reconstituted mice

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Zhang Y, Liu S, Ma JL, Chen C, Huang P, Ji JH, Wu D, Ren LQ

Thymol: This natural antifungal can also support the immune system and protect against toxins

This comprehensive approach will not only advance the field of liver disease therapy but also contribute to the broader understanding of nanomedicine applications in general diseases