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Role of acupuncture in the management of diabetic painful neuropathy (DPN): a pilot RCT

Abbreviations IGF-1: Insulin-like growth factor-1 GFBP 15 : Insulin-like growth factor binding proteins 15 BrCa: Breast cancer GH: Growth hormone IRS-1: Insulin receptor substrate 1 PI3K: Phosphatidylinositol 3-kinase MAPK: Mitogen-activated protein kinase ER-: Estrogen receptor - PR: Progesterone receptor SUMO: Small ubiquitin-like modifier BRCA1: Breast cancer 1-early onset protein KLF6: Kruppel-like factor 6 PARP1: Poly-ADP ribose polymerase 1 VHL: Von hippel lindau protein WT1: Wilms tumor 1 protein S6K1: Ribosomal protein S6 kinase 1 protein mTOR: Mammalian target of rapamyci HER2: Human epidermal growth factor receptor 2 protein SNP: Single-nucleotide polymorphism PBS: Phosphate buffer saline EMT: Epithelial to mesenchymal transition CTCs: Circulating tumor cells ECM: Extracellular matrix BD: Binding domain VEGFc: Vascular endothelial growth factor receptor c EGFR: Epidermal growth factor receptor TGF: Transforming growth factor UTRs: Untranslated regions EREL: Estrogen-responsive element-like site PGE2: Prostaglandin E2 ChIP: Chromatin immunoprecipitation COX-2: Cyclooxygenase-2 VN: Vitronectin ECR: Evolutionary conserved regions DFS: Disease-free survival TDLU's: Terminal duct lobular units BCSC: Breast cancer stem cell BCSS: BrCa-specific survival mAb: Monoclonal antibody RTKI: Receptor tyrosine kinase inhibitor IR: Insulin receptor References Ruan W, Kleinberg DL

In mouse models of colitis, oral KPV reduced the severity of disease triggered by both DSS and TNBS, two standard ways of inducing gut inflammation (Dalmasso et al., 2008)

Funding is capped at $6,500 for Phase I and $50,000 for Phase II