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The most commonly reported effects include: Nausea the most common, typically peaks in the first 48 weeks and decreases significantly as the body adjusts Reduced appetite expected and intentional

After fasting glucose was measured by glucometer, human regular insulin (0.1 U/kg, Lilly) was injected intraperitoneally

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To evaluate the quality of the selected RCTs, risk of bias was assessed using the revised Cochrane risk of bias tool for randomized trials (RoB 2.0) [33]