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9597 Peripheral activation of GLP-1 receptors triggers a cascade of metabolic effects, including slowed gastric emptying, reduced appetite, lower hepatic glucose production, enhanced insulin synthesis and sensitivity, and improved cardiovascular functions such as vasodilation and cardiac output

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Inhibitors of pyroptosis (VX-765 or AcYVAD) or necroptosis (necrostatin-1) did not rescue death induced by any of the SCLAs (Fig