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10.1111/j.2042-7158.2011.01393.x [DOI] [PubMed] [Google Scholar] Nagini, S

Regular use alongside balanced nutrition and exercise may support overall energy metabolism

Indirectly promotes: Muscle growth Lipolysis (fat breakdown) Collagen synthesis and tissue repair Bone density improvements Mechanistically, HGH activates: JAK2/STAT5 pathway for gene transcription IGF-1 production which then triggers anabolic action GH exerts its growth-promoting effects primarily through the stimulation of IGF-1, which acts in an endocrine, paracrine, and autocrine manner. Laron, Growth Hormone & IGF Research Insulin-like Growth Factor-1 (IGF-1) Produced by the liver in response to GH, but also delivered directly through peptide analogs like IGF-1 LR3 or IGF-1 DES