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The SURMOUNT-1 trial (tirzepatide, published in NEJM 2022) demonstrated that participants with obesity or overweight without diabetes who received tirzepatide experienced weight reductions of 16.0% (5mg), 21.4% (10mg), and 22.5% (15mg) over 72 weeks
Egrifta is FDA-approved for HIV-associated lipodystrophy
36 Five trials (COR-BMOD, 37 NCT02911818, 38 STEP 3, 36 SCALE IBT, 39 and SCALE Insulin trial) 31 specified IBT as a concomitant lifestyle therapy (comprising counselling, dietary advice, and increased physical activity)
In fact, one large analysis of more than 34,000 people found no increased risk compared to a placebo
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