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Supraphysiological doses of intravenous PYY3-36 cause nausea, but no additional reduction in food intake

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Metabolic Modulators: Multiple Phase I/II clinical trials have shown that the pyruvate dehydrogenase kinase (PDK) inhibitor dichloroacetate (DCA), used alone or in combination with chemoradiotherapy, demonstrates good safety and preliminary efficacy in some patients with advanced solid tumors [172, 173]

Targeted DNA methylation by homology-directed repair in mammalian cells