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The crosstalk between distinct RCDs is well documented and can be interpreted through the lens of the cell death-governing intracellular system with multiple redundant backup pathways [20, 142]

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Its a highly effective scavenger of free radicals and other reactive oxygen species (ROS) and reactive nitrogen species (RNS) such as the hydroxyl radical, lipid peroxyl radical, superoxide anion, and hydrogen peroxide, both directly and indirectly through enzymatic reactions 5

A few commenters recommended that future performance targets should move towards shorter time periods as the quality gap closes