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Two independent reviewers assessed each study to minimize bias

Pharmacokinetics Rapid Absorption: Intranasal delivery bypasses the gastrointestinal tract and hepatic metabolism, enhancing rapid onset of action compared to subcutaneous or oral administration

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[56] It achieves glycemic control primarily through a glucose-dependent mechanism: by binding to GLP-1 receptors on beta cells, it elevates intracellular levels of cyclic AMP (cAMP) and activates protein kinase A (PKA) and related signaling pathways