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4.5.2 Early pregnancy exposure: risk characterization under limited data Existing registry, cohort, and systematic-review data have not identified a stable pattern of major structural malformations after brief early-pregnancy exposure to GLP-1RAs, but the exposed human evidence base remains limited and heterogeneous

Until more information becomes available and out of an abundance of caution, alternative medications should be used while nursing

One end of the phospholipid molecule is attracted to water, while the other is attracted to fats

For example, DPP-IV inhibitors have been shown to promote beta-cell survival and function, characterized as augmented GSIS, in islets of non-diabetic and T2DM human donors (113, 114), demonstrating that ligands of DPP-IV enzymatic activity that function in a similar capacity to alpha-cell-derived proglucagon ligands are both present and active in isolated islets