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Administering an incorrect dosage can lead to exposure to side effects, or lessen efficacy

Thus, several ubiquitin-conjugating E2 enzymes (UBE2L3 and UBE2L5), the E3 ubiquitin ligases (TRIM21, TRIM38, and ARIH2) and the ubiquitin specific protease or deconjugases (USP13) are 1.53.2-fold induced in the infected cells, while other E2, E3 enzymes and deconjugases (e.g., UBE2D2/3, RNF214, USP4, USP47, and USP48) are 0.20.62-fold lower expressed (Table 1, Supplementary Table 3, and Figure 5A)

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Gut Microbes 16 , 2333463 (2024)