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10.1161/01.RES.0000119171.44657.45 Circ Res

Copper Metabolism Concerns Copper metabolism concerns represent theoretical risk of copper accumulation with prolonged use, though no documented cases of copper toxicity at recommended doses exist in literature

5 Causes and Risk Factors for Acetaminophen & NSAID Toxicity Acetaminophen Liver necrosis, the primary outcome of acetaminophen toxicity in humans, is predominantly a function of overdose (Hinson 2010)

Excess copper can promote ferritin depletion and disrupt iron metabolism, thereby sensitizing cardiomyocytes to ferroptosis, a process that synergistically aggravates I/R injury [67]