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For clinicians, understanding and clearly communicating these mechanisms can enhance patient trust, adherence, and long-term outcomes

Wegovy Wegovy is available on the NHS if you have weight-related health issues and a BMI of either: Liraglutide Liraglutide and Saxenda are suitable for adults aged up to 75 and can only be prescribed if the following apply: Orlistat Orlistat and its branded alternative, Xenical, are available on the NHS if you have already made a significant effort to lose weight by changing your lifestyle and if you have a BMI of: To qualify for prescription weight loss treatment, you need to have a BMI of over 30, or over 27 or 28 with certain other medical problems, but this depends on the medication

In MELAS, seizures occur with a frequency ranging from 71 to 96% (26), and typically present as generalized tonicclonic seizures, focal seizures, or generalized status epilepticus (27)