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The metabolically active forms of GLP-1 are the endogenous GLP-1-(7-36)NH 2 and the more rare GLP-1-(7-37)

With the exception of WY-14,643, these agents produce a transient hyperplasia with subsequent hepatocellular hypertrophy

It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)

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