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It is engineered to bind with high affinity to three distinct receptor sites, creating a metabolic environment conducive to rapid fat oxidation and glycemic control

They share the same three primary receptor targets: GLP-1 GIP Glucagon Because of this shared mechanism, both compounds are part of the broader movement toward multi-agonist incretin drugs designed to influence several metabolic hormone systems simultaneously

A 2023 New England Journal of Medicine Phase 2 study evaluated Retatrutide in a randomized, placebo-controlled human research design