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Dietary long-chain fats are significantly reduced while ensuring that levels of essential fatty acids, such as alpha-linoleic acid and linoleic fatty acids, are sufficient [32, 33]

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however, owing to dynamic changes in disease energy metabolism, where early-stage tumors rely on glycolysis and advanced stages on fatty acid oxidation (FAO), treatment efficacy is often sub-optimal

In the mentioned country, the cost of the burden of disease in 2013 was estimated to be over 20 billion dollars [1, 3]