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Naltrexone is best known for its use in addiction medicine but is increasingly recognized as a valuable tool in weight management

Moreover, a few GLP-1 RAs (dulaglutide, liraglutide and semaglutide) are now indicated to reduce cardiovascular risk in people with type 2 diabetes and established cardiovascular disease, and a protective effect of GLP-1 RAs on the kidneys is suggested from a range of cardiovascular outcome trials (CVOTs) in type 2 diabetes [135,136,137,138]

A stable asymptomatic patient who took weekly semaglutide three days ago may not require cancellation, whereas a patient who took the same medication ten days ago but has persistent vomiting and bloating may remain high risk