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Efficacy and safety of once-weekly cagrilintide for weight management: a randomised, placebo and active-controlled, dose-finding phase 2 trial Summary: This Phase 2 dose-finding trial investigated the efficacy and safety of cagrilintide monotherapy for weight management

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However, the patients enrolled in EMPA-REG had little CKD at the start of the trial

Summary: Weight loss plateaus with Wegovy commonly occur due to metabolic adaptation, dietary adherence changes, fluid retention, underlying medical conditions, or medication interactions, rather than treatment failure