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2018;27: 12121221.e3

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial

Once opened and first injected, the multi-dose pen or vial maintains integrity for the full 28-day window if temperature consistency is preserved

[000219] Mechanistically, given the specificity of anti-CD3 monoclonal antibody in targeting T cells, the findings point toward a T cell-driven remodeling of the myeloid compartment as central to the observed improvements