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The consideration of cysteine during these simulations were important, as cytosolic cysteine is the rate limiting amino acid precursor for synthesis of GSH, via the -glutamylcysteine synthetase (GCS) enzyme, and this is a function of its reduced concentration compared to the other precursors, glycine and glutamate
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This toxic metabolite of VPA has a suspected toxic effect [97], and studies of its toxic potential are ongoing
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It is well known that inflammation is linked with breakdown of the blood-retinal barrier, which results in vascular dysfunction and edema
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