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Studies have shown that when amyloid-beta and tau are increased, the cells ability to neutralize oxidative stress and mitochondria specific ROS is decreased leading to further tau hyperphosphorylation and neurodegeneration (Alavi Naini and Soussi-Yanicostas 2015)

Beyond its antioxidant power, glutathione also plays a key role in cellular function and nutrient metabolism

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Some compounds that protect hair cells from aminoglycoside exposure, for example tacrine and other quinoline ring-containing structures, do so by inhibiting aminoglycoside uptake (Ou et al., 2009, 2012)