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RiskBenefit Assessment and Pharmacovigilance Needs Given the widespread use of GLP-1RAs and other incretin-based agents for obesity and T2D, comprehensive evaluation of even common GI adverse effects remains limited

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Cancer immunotherapy (Checkpoints Inhibitors): Drugs like pembrolizumab (Keytruda) and nivolumab (Opdivo) have been through both NICE and ICER