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Nanoparticle systems enable the co-delivery of ferroptosis inducerssuch as GPX4 inhibitorsand immune checkpoint blockade agents like anti-PD-L1 antibodies directly to the tumor site, thereby increasing local drug concentration while minimizing systemic toxicity (144, 145)

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FFPE breast tumor sections (4 m thickness) were subjected to immunohistochemistry (IHC) as described [38] with some modifications

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