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[5] [6] However, the absolute risk remained low , and the study's observational design could not definitively establish causation

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HOLST: The Gila monster, it was actually a great inspiration, so the study where we demonstrated the effect in diabetes was from 1993, and that's what convinced at least some of the pharmaceutical companies, and certainly Novo Nordisk in Denmark, that perhaps it was worthwhile working with this peptide, and that's why, that's when they started developing what later became liraglutide or Victoza