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Platelet activation triggers further leukocyte activation and promote RBC adhesion to an exposed endothelium ( ex vivo studies, and was well tolerated by patients, but on a 24-month follow up, patients on the treatment arm failed to show reduction in the frequency of VOC (Kanter et al., 2019) (ClinicalTrials.gov identifier: NCT02482298)

Trained men who exercised to exhaustion on a treadmill had increased blood amounts of oxidized glutathione immediately after exercise, suggesting an increase in oxidative stress, but returned to rest after 1 h

Intravenous immunoglobulin: an update on the clinical use and mechanisms of action

Metabolic dysfunction-associated fatty liver disease and implications for cardiovascular risk and disease prevention