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Description

The immunogenic potential of GLP-1 peptide receptor agonists is influenced by their peptide structure and foreignness to the human immune system

Lee HJ, Ha SJ, Lee SJ, Kim JW

The study highlighted that no endogenous MGF E-peptide has been isolated from in vivo tissue raising questions about whether the synthetic 24-aa peptide faithfully replicates any endogenous cleavage product

One form was given intravenously as a fat emulsion resembling chylomicrons and the other was administered orally with a defined liquid meal