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The enhanced toxicity to metformin in the older worms was linked to reduced mitochondria abundance and the reduced ability to generate ATP see Table 1 for details (72)

To exchange codon CTC of the IR encoding leucine-973 to codon TTC encoding phenylalanine-973, we performed pronucleus injections

Fruhwirth GO, Moumtzi A, Loidl A, Ingolic E, Hermetter A

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