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J Pharm Pharmacol 2015;67(7):879-899

It can be clinically relevant to appreciate that these secondary effects of vitamin B 12 deficiency could be central to its pathophysiology

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In summary, the aforementioned information indicates that ATZ reduced the levels of FSH and LH hormones, which subsequently resulted in decreased testosterone levels, either through the induction of oxidative stress in the testes or by impairing steroidogenic genes, thereby disrupting spermatogenesis and compromising semen quality