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Sanofi has submitted a new drug application for lixisenatide in the US (the trade name has not been determined in the US yet), and on February 19 the FDA accepted the application

The Reuters report on a head-to-head trial against tirzepatide (February 2026) noted CagriSema did not meet a non-inferiority threshold against tirzepatide on average weight loss at 84 weeks

A short non-diabetic cohort measured a flat 2.5 mg dose for about four weeks and found weight and insulin-resistance movement (about -4.7% body weight). That makes "2.5 mg has no data" outdated

This is especially common for those who feel theyve built solid habits around food and exercise during treatment