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Semaglutide administration is performed via subcutaneous injection once weekly on the same day

Along with the reported imbalances between pro-inflammatory and anti-inflammatory cytokines, which have been reported to play an important role in initiation and pathogenesis of arthritis, prostaglandins, nitric oxide, and reactive oxygen species (ROS) are also released at the site of inflammation in many rheumatic diseases, damaging the cartilage and the components of extracellular matrix

Lancet (London, England), 398(10317), 21602172

Large randomized controlled trials show that 2026% of semaglutide users report constipation, making it a common but not universal side effect