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Given the tight relationship between mitochondrial function and morphology (Petit et al., 1995), that has been observed in HC-treated cells

It was given (i) intraperitoneally or (ii) intragastrically or (iii) topically at the swollen brain through an additional midline burr hole placed approximately 2 mm rostral to the horizontal line connecting the two parasagittal burr holes, making a triangle with them and overlying the sagittal sinus in the dural