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4.3 Dipeptidyl peptidase-4 enzyme inhibitors Glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted by intestinal cells that stimulates insulin secretion from pancreatic cells in response to blood glucose

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Subsequent increases in the permeability of the intestinal barrier in CKD patients promote the translocation of bacterial products of intestinal origin, such as LPS, uremic toxins, and cytokines, into the systemic circulation, resulting in local and systemic inflammation, as well as oxidative stress associated with CKD (Krukowski et al., 2023

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