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The starting dose, intended to gauge tolerance and initial response, aligns with standard practices in early-phase clinical trials where safety is paramount

Larger meal volume and higher energy density slow gastric emptying, and when combined with GLP-1mediated slowing , this can amplify post-meal fullness, bloating, and discomfort. Carbonation and rapid eating Behaviors that can amplify bloating and gas include: Soda, sparkling water, or beer Drinking carbonated beverages with meals Eating quickly or while distracted Continuing to eat past early fullness Skipping pauses between bites, Does simethicone (Gas-X) help sulfur burps, bloating, or gas on GLP-1 medications

10.1111/j.1365-2141.1961.tb00318.x Br

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