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A comprehensive 2025 review in Molecules compiled evidence that the AEDG peptide has been studied for its influence on expression of key antioxidant genes, including SOD2 (superoxide dismutase 2), CAT (catalase), and HMOX1 (heme oxygenase-1) (8)

doi:10.1002/jcp.21040 Russell AJ, Fincher EF, Millman L, Smith R, Vela V, Waterman EA, Dey CN, Guide S, Weaver VM, Marinkovich MP (2003) Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin

High affinity binding sites are located at the N-terminal domain and the first Kringle domain of the -chain

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