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Other long-term toxicities Beyond the aforementioned target organ toxicities, long-term cohort studies have confirmed that platinum-based chemotherapy induces multiple delayed long-term adverse outcomes (manifesting years to decades post-chemotherapy, severely impairing cancer survivors long-term survival), including reproductive toxicity, cardiovascular toxicity, and elevated second primary neoplasm (SPN) risk

In this review, we describe the metabolic transformation in cancer cells, then summarize different roles of glutamine in cancer metabolism in biosynthesis and stress protection

The most common time to see side effects like these are when you initially start the medication or when you are increasing the dose

In this context, the oncogenic transcription factor c-myc plays a key role in the induction of glutamine addiction [18,33]