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Carnethon MR, De Chavez PJD, Lauderdale DS, Carson AP, Liu K, Knutson KL

Furthermore, in human reviews 3 of muscle protein metabolism, activation of IGF-1/Akt/mTOR signaling directly correlated with higher protein synthesis rates and improved muscle density, particularly in response to resistance training and nutrient intake

Compared with the saline control, both r-sFNDC5 and r-irisin reduced the weight of mouse epididymal fat and the body weight of HFD mice (0.284.59 g) (Figures 6A,B)