Extrapolating to a 70 kg human gives an approximate dose of 700 mcg, which sits within the 500, 1 to 000 mcg range sometimes prescribed off-label
Because DSIP was originally linked to delta-wave sleep activity, it became known as delta sleep-inducing peptide. That name can make DSIP sound more proven than it actually is
Like ME/CFS, MS is most prevalent in women [223], the specific aetiology is unknown, and there is evidence of differential TRP channel expression [224], including TRPM3 expression in PBMCs compared to healthy controls [225], increased activation [226], mitochondrial dysfunction and oxidative stress [227, 228] in PBMCs
The practical difference for most people is minimal, though methylcobalamin skips the conversion step and may be preferable for individuals with certain genetic variations affecting B12 metabolism