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( 11 ) provide compelling evidence that GLP-1 signaling in the CNS also serves to increase noninsulin-dependent glucose uptake by muscle and stimulates insulin secretion via neural connections to these tissues.

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Now known as the FoyerHalliwellAsada pathway, this sequence of reactions notably links reduction of H 2 O 2 , catalysed by ascorbate peroxidase, to oxidation of NADH or NADPH, catalysed by monodehydroascorbate reductase and glutathione reductase