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Thus, central GHR ablation likely impaired GH negative feedback, leading to increased body growth, especially in brain GHR KO mice
Tamoxifen, a selective estrogen receptor modulator and antagonist of ER in breast tissue, is a commonly used adjuvant therapy for patients with ER-positive breast cancer (133)
Compounds such as thalidomide and its analogs lenalidomide and pomalidomide promote interactions between E3 ligases (e.g., cereblon) and specific target proteins, triggering their ubiquitination and proteasomal degradation
Abnormal potassium ion channels may accelerate pathological -Syn accumulation, increasing the risk of PD
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