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In our review of the literature, we did not find any prospective clinical studies with sufficient evidence to support the use of metformin, melatonin, tranexamic acid, vitamins A, C, D, E, niacinamide, or zinc in the treatment of skin aging
Nematizadeh, M., Ghorbanzadeh, H., Moghaddam, H
This breadth is both the compound's strongest argument and a source of appropriate scientific skepticism: a compound that seems to fix everything tends to invite scrutiny about study quality and publication bias
Understanding what to expect and how to respond makes the difference between a rough first few weeks and an unnecessarily miserable experience
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