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Experts recommend beginning collagen supplementation with a minimal dose to observe skin reaction

Am J Physiol Endocrinol Metab (2019) 317(6):E1108e20

The 2025 EMJ Dermatology scoping review reached the same conclusion: low-molecular-weight HA penetrates the dermis while high-molecular-weight HA delivers surface hydration and barrier protection

Discuss the importance of having access to an opioid overdose reversal agent, especially if the patient has risk factors for overdose (e.g., concomitant use of CNS depressants, a history of opioid use disorder, or prior opioid overdose) or if there are household members (including children) or other close contacts at risk for accidental ingestion or opioid overdose