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Although some studies have demonstrated that a high-altitude hypoxic environment can cause damage to male testicular reproductive function and negatively affect male semen quality, the specific mechanism is not completely clear

Freezing and thawing which can occur multiple times throughout production and use of protein therapeutics can dramatically affect protein aggregation

A plethora of other gut released peptides exist to be explored: Amylin [46] , peptide YY (PYY) [47] , Cholecystokinin (CCK), secretin, neurotensin, somatostatin (SST) and ghrelin to name a few