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The fluid shear stress sensor TRPM7 regulates tumor cell intravasation

Perlmutters books have been published in 32 languages and include the #1 New York Times bestseller Grain Brain, The Surprising Truth About Wheat, Carbs and Sugar, with over 1 million copies in print

Comparative evaluation of redox-responsive linkages (disulfide, thioketal, and boronate) and scaffold architectures (hydrogels, nanofibers, 4D-printed matrices) were performed to elucidate their role in modulating redoximmune balance and tissue regeneration

Its selective permeability, governed by tight junctions, transport proteins, and metabolic enzymes, severely restricts brain penetration of macromolecular therapeutics, necessitating high systemic doses that cause hepatotoxicity and immunosuppression