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Common GLP-1 Side Effects You Are More Likely to Experience Nausea ranks as the most frequent side effect, affecting 2540% of semaglutide users during the first weeks of therapy

Contact your healthcare provider if you experience significant changes in mood, persistent depression or anxiety, social withdrawal, or any behavioral changes that concern you or your family members

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Protein shakes may help with nutrition intake when experiencing GLP-1 side effects: Side effects such as low appetite and nausea can occur while on GLP-1s and protein shakes can be a helpful source of nutrition when you do not feel like eating much or at all