Bollino D, Balan I, Aurelian L
Testing is recommended before initiating therapy Kidney stones: High-dose vitamin C metabolizes to oxalate, which can increase kidney stone risk in susceptible patients Interference with lab tests: High-dose vitamin C can interfere with certain blood glucose meters and occult blood tests Iron absorption: Vitamin C significantly enhances dietary iron absorption caution in patients with iron overload Common Side Effects Injection site pain, bruising, or swelling Mild flushing or warmth Nausea Headache Unusual taste in the mouth Mild fatigue Temporary increase in urination (vitamin C is water-soluble) Seek Medical Attention For Signs of allergic reaction: rash, swelling, difficulty breathing Severe flank or back pain (possible kidney stone) Signs of hemolysis: dark urine, jaundice, severe fatigue Severe injection site reaction or infection Drug Interactions High-dose vitamin C may reduce the effectiveness of certain chemotherapy agents Vitamin C can enhance iron absorption from supplements May affect warfarin anticoagulation (rare)
Who Should Not Undergo This Procedure Based on current clinical understanding, IV glutathione infusions are generally not appropriate for: Individuals who are pregnant or breastfeeding Patients with a history of kidney or liver disease Those with a known allergy to glutathione, ascorbic acid (Vitamin C), or any other component of the infusion Individuals with certain autoimmune or haematological conditions these should be assessed and discussed with a doctor Comparing IV Glutathione to Evidence-Based Skin-Brightening Treatments For patients with concerns about skin tone, hyperpigmentation, melasma, post-inflammatory hyperpigmentation (PIH), or solar lentigines, a range of treatments with a more established evidence base are available in Singapore
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