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Here we studied the effects of semaglutide on the circulating proteome using baseline and end-of-treatment serum samples from two phase 3 trials in participants with overweight or obesity, with or without diabetes: STEP 1 ( n = 1,311) and STEP 2 ( n = 645)
It is a hormone classified as an incretin , meaning it is released by the gut in response to food intake and stimulates insulin secretion
By inhibiting gastric emptying, GLP-1 also improves blood sugar excursion, delays food absorption, and is therefore a regulator of satiety and appetite also through the hypothalamus (63)
protects against colitis-associated cancer via PepT1 pathway
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