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Byrne SJ, Dashper SG, Darby IB, Adams GG, Hoffmann B, Reynolds EC

HA attracts water, integrates smoothly, and can be dissolved with hyaluronidase if needed

Glossary AREs antioxidant response elements AARE amino acid response element ATF3 Activating transcription factor 3 ATF4 Activating transcription factor 4 ABCC5 ATP-binding Cassette Subfamily C Member 5 AIFM2 apoptosis-inducing factor mitochondria-associated 2 BRD4 Bromodomain-containing protein 4 BSO buthionine sulfoxide BACH1 BTB and CNC homology 1 CGL cystathionine -lyase BCAT2 Branched-chain amino acid aminotransferase 2 CREB cyclic adenosine monophosphate response element binding protein CHaC1 Gamma-Glutamylcyclotransferase 1 CDO1 Cysteine dioxygenase 1 CRC colorectal cancer CSCs colorectal cancer stem cells CoQ10 coenzyme Q10 DUB deubiquitinase DAZAP1 DAZ Associated Protein 1 EGFR Epidermal Growth Factor Receptor EP300 E1A binding protein P300 GSH glutathione FSP1 Ferroptosis suppressor protein 1 GPX4 glutathione peroxidase 4 GCL glutamate cysteine ligase GSS glutathione synthetase GCLC Glutamate-Cysteine ligase Catalytic Subunit GCLM Glutamate-Cysteine ligase Modifier Subunit GC gastric cancer GSTZ1 Glutathione S-transferase zeta 1 GDF15 Growth/differentiation factor 15 H3K9 H3 lysine 9 HSPA5 Heat shock protein A family member 5 HDACI histone deacetylase inhibitor HCC Hepatocellular Carcinoma HNF4 hepatocyte nuclear factor 4 HIC1 HIC ZBTB Transcriptional Repressor 1 HBV hepatitis B virus IKE imidazole ketone Erastin IPP isopentenyl pyrophosphate Keap1 Kelch-like ECH-associated protein 1 KRAS Kirsten Rat Sarcoma LOX lipoxygenase LOOHs lipid hydroperoxides LCN2 Lipocalin 2 Lipocalin 2 LUAD lung adenocarcinoma LONP1 Lon peptidase 1 LCN2 Lipocalin 2 Lipocalin 2 LSH Lymphoid-specific helicase MDA malondialdehyde MUC1 mucin glycoprotein Mucin 1 m6A N6 -methyladenosine MT-1G Metallothionein-1G MTOR mechanistic target of rapamycin kinase MCU mitochondrial calcium uniporter Nrf2 nuclear factor erythroid 2-related factor 2 NUPR1 Nuclear Protein 1 OTUB1 OTU deubiquitinase, ubiquitin aldehyde-binding 1 PE Piperazine Erastin p53 Tumor protein p53 PLOOH phospholipid hydroperoxide PUFAs polyunsaturated fatty acids PdPT palladium pyrithione complex PCDHB14 Protocadherin Beta 14 PSTK Phosphoseryl-tRNA kinase RSL3 RAS-selective lethal small molecule 3 RCD regulatory cell death ROS reactive oxygen species RRM2 Ribonucleotide reductase regulatory subunit M2 Rb retinoblastoma

thyroid, kidney, or liver dysfunction, skin rash, and complications with intravenous catheters such as infection and inflammation of the vein