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As biological agents, they could be beneficial or they could be harmful. Mandelbaum said there are a variety of orthobiological compounds that have been proven safe and effective for supporting healing

However, they work only while you take them, do nothing to promote tissue repair, and carry risks of gastrointestinal, cardiovascular, and renal side effects with prolonged use

They reinforce the communication those systems depend on to function, rather than overriding those systems

While no direct contraindication exists for concurrent use, the absence of controlled trials means safety and efficacy remain inadequately characterized